Amphibian populations are faced with an onslaught of environmental problems, including pollution, infectious diseases, habitat loss, invasive species, climate change, and over-harvesting for the pet and food trades.
They are considered to be indicator species for environmental health:
http://www.karlonia.com/2008/08/25/how-to-get-rid-of-frogs/
they have delicate skin that readily absorbs toxins from their environment; they have few defenses and can fall prey to non-native predators; they rely on both aquatic and terrestrial habitats (video) at various times during their life cycle.