Blabberize (www.blabberize.com) is a neat tool that can be used at any grade level. It allows you to upload any photo, create a "mouth" on the object, and record speech.  I would encourage you to watch the example on the website to get an idea of what the website can be used for.  

It would be an ideal tool for students who have good senses of humor and do not respond welll to a traditional style of teaching such as lecture and writing notes.  A great example of using blabberize would be a high school english class starting Shakespeare.  You could upload a photo of Shakespeare and then record a speech in first person and have Shakespeare himself discuss his history and his ideas about whatever play or poem you are discussing.  Or a student who had difficulties arituclating themselves through a written reflection could upload a picture of themselves and "blabberize" it to present their ideas.